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  • Title: Cytotoxic and antibacterial sesquiterpenes from Thespesia populnea.
    Author: Boonsri S, Karalai C, Ponglimanont C, Chantrapromma S, Kanjana-Opas A.
    Journal: J Nat Prod; 2008 Jul; 71(7):1173-7. PubMed ID: 18553924.
    Abstract:
    Eight new sesquiterpenoids, named populene A-H (1-8), were isolated from dichloromethane extracts of the wood and dark heartwood of Thespesia populnea, together with 11 known compounds (9-19). Their structures were determined on the basis of spectroscopic analyses. The cytotoxic activity of isolated compounds was evaluated against four cancer cell lines: MCF-7, HeLa, HT-29, and KB. Mansonone E (11) and (+)-gossypol (18) showed significant activities. Their antibacterial properties against Bacillus subtilis, Staphylococcus aureus, and Enterococcus faecalis are also presented.
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