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  • Title: Relationship between serum progesterone and tumor necrosis factor production in postmenopausal women undergoing estrogen/medroxyprogesterone therapy.
    Author: Stopińska-Głuszak U, Jóźwiak J, Radomski D, Głuszak O, Roszkowski PI, Malejczyk J.
    Journal: Fertil Steril; 2009 Apr; 91(4 Suppl):1344-6. PubMed ID: 18554598.
    Abstract:
    Changes in tumor necrosis factor (TNF) production by lipopolysaccharide-stimulated peripheral blood mononuclear cells significantly correlated with serum P levels in postmenopausal women subjected to estrogen/medroxyprogesterone therapy. This may suggest that low physiologic or hormone therapy-related changes of serum P in healthy postmenopausal women may affect an ability of peripheral blood mononuclear leukocytes to produce TNF, thus having an impact on a variety of TNF-dependent physiologic and pathologic phenomena.
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