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  • Title: Histological and molecular temporomandibular joint analyses after mandibular advancement surgery: study in minipigs.
    Author: de Lima Navarro R, Oltramari PV, Sant'Ana E, Henriques JF, Taga R, Cestari TM, Conti PC, Cunha FQ, Santos CF.
    Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 2008 Sep; 106(3):331-8. PubMed ID: 18554945.
    Abstract:
    OBJECTIVES: The objective of this study was to elucidate the changes occurring in the temporomandibular joint (TMJ) after surgical mandibular advancement with different fixation techniques: bicortical screws (rigid fixation) and miniplates (semi-rigid fixation). STUDY DESIGN: Eighteen minipigs were equally and randomly divided into 3 groups: Group I (control), nonoperated animals; Group II, animals submitted to surgical advancement surgery and osteosynthesis by bicortical screws; and Group III, animals submitted to surgical advancement surgery and osteosynthesis by miniplates. Four months after the surgeries, the presence of interleukin (IL)-6 and IL-10 in synovial fluid samples was assessed in ELISA experiments. TMJs were histologically prepared. RESULTS: Higher levels of IL-10 (P = .0436) were found for Group II. Descriptive histological analysis was compatible with the ELISA findings. CONCLUSIONS: Rigid fixation evokes more pronounced signs of bone remodeling in the TMJ, whereas malleable fixation promotes a more intense inflammatory activity. Therefore, rigid fixation seems to transmit a higher impact of postoperative masticatory forces to the TMJ.
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