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  • Title: [Technology of vitamins containing double layer suppositories].
    Author: Bakuridze AD, Maglakelidze GM, Kurdiani NG, Tsagareishvili NT, Berashvili DT.
    Journal: Georgian Med News; 2008 May; (158):49-51. PubMed ID: 18560041.
    Abstract:
    At present ascorbic acid and cyanocobalamin are widely used in medical practice. Often they are administered simultaneously; chemically they are incompatible, as ascorbic acid (redox compound) inactivates cyanocobalamin. The combination of ascorbic acid and cyanocobalamin is the problem of pharmacy. To solve the problem double-layer suppositories containing two incompatible vitamins: ascorbic acid and cyanocobalamin were developed. Pharmaceutical bioavailability of ascorbic acid and cyanocobalamin has been studied using in-vitro methods to develop optimal base for suppositories. As a result of investigations optimal composition and technology of the double-layer suppositories containing ascorbic acid and cyanocobalamin which met requirements has been developed. Sequential release of active compounds and as a result - sequential pharmacologic action is achieved.
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