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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Sorafenib-induced palmoplantar hyperkeratosis.
    Author: Lountzis NI, Maroon MS.
    Journal: J Drugs Dermatol; 2008 Jun; 7(6):588-9. PubMed ID: 18561593.
    Abstract:
    Sorafenib is an oral multikinase inhibitor used in the treatment of renal cell carcinoma. As with single kinase inhibitors, cutaneous adverse events have been reported with sorafenib, specifically a hand-foot reaction complicated by hyperkeratosis. The authors highlight the case of a 51-year-old Caucasian woman treated for metastatic renal cell carcinoma who presented with well-defined tender erythematous callosities of the fingers and feet, following a dosage increase of sorafenib. A dose reduction decreased the symptoms, but the hyperkeratosis persisted. This adverse response may represent a novel event differing from traditional hand-foot syndrome.
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