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  • Title: Detection of C-reactive protein on a functional poly(thiophene) self-assembled monolayer using surface plasmon resonance.
    Author: Kim HC, Lee SK, Jeon WB, Lyu HK, Lee SW, Jeong SW.
    Journal: Ultramicroscopy; 2008 Sep; 108(10):1379-83. PubMed ID: 18565665.
    Abstract:
    The preparation of a new poly(thiophene) with pendant N-hydroxysuccinimide ester groups and its application to immobilization of biomolecules are reported. A thiophene derivative of N-hydroxysuccinimide ester was polymerized with FeCl3 in chloroform and the resulting poly(thiophene) was characterized by nuclear magnetic resonance (NMR), Fourier transform infrared (FT-IR), and gel permeation chromatography (GPC). This polymer reacts with amine-bearing molecules to yield new poly(thiophene) derivatives and the specific interactions at the side groups could be detected. Thus, a self-assembled monolayer (SAM) using the polymer was formed on a gold-coated quartz cell and anti-C-reactive protein (anti-CRP) was immobilized. The binding behavior of CRP on the surface was monitored by use of a surface plasmon resonance (SPR) sensor system.
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