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  • Title: Effects of phenolic compounds isolated from Rabdosia japonica on B16-F10 melanoma cells.
    Author: Nitoda T, Isobe T, Kubo I.
    Journal: Phytother Res; 2008 Jul; 22(7):867-72. PubMed ID: 18567053.
    Abstract:
    Pedalitin isolated from the aerial part of Rabdosia japonica (Labiatae), exhibited cytotoxicity against the murine B16-F10 melanoma cell line with an IC(50) of 30 microm (9.5 microg/mL). As the cells were cultured with this flavone, melanin production was not suppressed, but rather enhanced. Quercetin isolated from the same source exhibited similar activities, but rutin showed neither activity.
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