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  • Title: Cytochrome c: functions beyond respiration.
    Author: Ow YP, Green DR, Hao Z, Mak TW.
    Journal: Nat Rev Mol Cell Biol; 2008 Jul; 9(7):532-42. PubMed ID: 18568041.
    Abstract:
    Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions.
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