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  • Title: [Diabetes mellitus and heart failure: epidemiology and therapy].
    Author: Pfister R, Erdmann E.
    Journal: Herz; 2008 Apr; 33(3):178-83. PubMed ID: 18568311.
    Abstract:
    Diabetes mellitus and heart failure show a high coincidence, promote pathogenesis and worsen prognosis of each other. Currently, there are no prospective studies evaluating a specific antidiabetic or cardiologic therapy in diabetic patients with heart failure. Furthermore, a favorable effect of optimized glycemic control on the progression of heart failure has not been proven yet. Retrospective analyses indicate a rather positive effect of the insulin sensitizers metformin and glitazones and a neutral or rather negative effect of insulin and sulfonylureas in diabetic patients with heart failure. Up to now, due to missing prospective, controlled trials no evidence-based antidiabetic therapy can be recommended in diabetic heart failure patients.
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