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  • Title: Correlating the cochleovestibular deficits with tumor size of acoustic neuroma.
    Author: Day AS, Wang CT, Chen CN, Young YH.
    Journal: Acta Otolaryngol; 2008 Jul; 128(7):756-60. PubMed ID: 18568517.
    Abstract:
    CONCLUSION: The tumor size of acoustic neuroma correlates with cochleovestibular deficits. Those tumors with global frequency hearing loss, bilateral gaze nystagmus, or absent caloric and VEMP responses may indicate a tumor size >2.5 cm. OBJECTIVE: This study aimed to investigate the correlation between cochleovestibular deficits and the size of acoustic neuroma. PATIENTS AND METHODS: A total of 44 patients with acoustic neuroma were enrolled in this study. Pure tone audiometry, electronystagmography, caloric test, vestibular evoked myogenic potential (VEMP) test, and MRI were conducted. RESULTS: There is a trend of correlation between tumor size and audiographic configuration, with small-sized tumor in normal and rising types, medium-sized tumor in mid- and high-frequency hearing loss, and large-sized tumor in flat and deafness types. Five patients with bilateral gaze nystagmus had significantly larger tumor size than those without nystagmus. When 1 and 0 are used to represent abnormal and normal responses, respectively, the relationship between tumor size and vestibular function can be expressed as: tumor size (cm)=1.43 (caloric response)+1.35 (VEMP response), indicating that the estimated tumor size for those with abnormal caloric or VEMP responses increased by 1.43 or 1.35 cm, respectively.
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