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  • Title: Aspergillus fumigatus antigens activate immortalized human corneal epithelial cells via toll-like receptors 2 and 4.
    Author: Zhao J, Wu XY.
    Journal: Curr Eye Res; 2008 May; 33(5):447-54. PubMed ID: 18568882.
    Abstract:
    PURPOSE: To evaluate the role of toll-like receptors (TLR) 2 and 4 in host responses to Aspergillus fumigatus by use of cultured telomerase-immortalized human corneal epithelial cells (HCECs). METHODS: HCECs were stimulated with inactive antigens from A. fumigatus. The expression of TLR2 and TLR4, phosphorylation of Ikappa B-alpha (pIkappa B-alpha), and release of interleukin (IL)-1beta and IL-6 was measured with and without inhibitors to TLR2 and TLR4. RESULTS: Exposure of HCECs to A. fumigatus antigens resulted in up-regulation of TLR2 and TLR4, activation of pIkappa B, and release of IL-1beta and IL-6 in HCECs, effects that could be inhibited by treatment with TLR2 and TLR4 antibodies. CONCLUSIONS: TLR2 and TLR4-nuclear factor-kappa B signaling pathways in corneal epithelium play important roles in inflammatory responses against A. fumigatus antigens.
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