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  • Title: [Expression and clinical significance of microtubule-associated protein 1 light chain 3 (LC3) and Beclin1 in epithelial ovarian cancer].
    Author: Shen Y, Liang LZ, Hong MH, Xiong Y, Wei M, Zhu XF.
    Journal: Ai Zheng; 2008 Jun; 27(6):595-9. PubMed ID: 18570732.
    Abstract:
    BACKGROUND & OBJECTIVE: Some studies have showed that changes of autophagic capacity may be correlated to tumorigenesis and tumor development. This study was to investigate the expression of microtubule-associated protein 1 light chain 3 (LC3) and autophagy-related gene Beclin1 in ovarian tumor tissues, and explore their correlations to the tumorigenesis and development of epithelial ovarian carcinoma. METHODS: Expressions of LC3 and Beclin1 in 25 specimens of benign ovarian tumor, 25 specimens of borderline ovarian tumor, and 75 specimens of epithelial ovarian carcinoma were detected by immunohistochemistry. The correlations of LC3 and Beclin1 expression to the clinicopathologic characteristics of the 75 epithelial ovarian cancer patients were analyzed. RESULTS: The positive rates of LC3 and Beclin1 were significantly higher in benign and borderline ovarian tumors than in epithelial ovarian carcinoma (100% and 96% vs. 57%, P<0.001; 100% and 84% vs. 57%, P<0.001). The expression of LC3 was associated with FIGO stage and histological grade (P=0.017;0.001). The expression of Beclin1 was related to FIGO stage (P=0.04). The expression of LC3 was not correlated to Beclin1 (P=0.875). CONCLUSIONS: Expressions of LC3 and Beclin1 are down-regulated in epithelial ovarian cancer tissues. The decrease of autophagic capacity may relate to tumorigenesis and the development of epithelial ovarian cancer.
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