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  • Title: Discovery of new Gram-negative antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors.
    Author: Moreau F, Desroy N, Genevard JM, Vongsouthi V, Gerusz V, Le Fralliec G, Oliveira C, Floquet S, Denis A, Escaich S, Wolf K, Busemann M, Aschenbrenner A.
    Journal: Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4022-6. PubMed ID: 18571407.
    Abstract:
    Heptosyltransferases such as WaaC represent promising and attractive targets for the discovery of new Gram-negative antibacterial drugs based on antivirulence mechanisms. We report herein our approach to the identification of the first micromolar inhibitors of WaaC and the preliminary SAR generated from this family of 2-aryl-5-methyl-4-(5-aryl-furan-2-yl-methylene)-2,4-dihydro-pyrazol-3-ones identified by virtual screening.
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