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  • Title: A comparison of urinary albumin-total protein ratio to phase-contrast microscopic examination of urine sediment for differentiating glomerular and nonglomerular bleeding.
    Author: Ohisa N, Yoshida K, Matsuki R, Suzuki H, Miura H, Ohisa Y, Murayama N, Kaku M, Sato H.
    Journal: Am J Kidney Dis; 2008 Aug; 52(2):235-41. PubMed ID: 18572288.
    Abstract:
    BACKGROUND: Hematuria can be classified as either glomerular or nonglomerular, depending on the bleeding source. We recently reported that urinary albumin-total protein ratio is potentially useful for identifying the source of hematuria. STUDY DESIGN: Diagnostic test study. SETTING & PARTICIPANTS: 579 fresh urine specimens with microhematuria (> or =5 red blood cells/high-power field) collected from patients with the source of the hematuria confirmed on histopathologic and/or imaging studies and clinical criteria assessed. INDEX TEST: Each urine specimen was evaluated morphologically by using phase-contrast microscopy and biochemically by using urinary albumin-total protein ratio, albumin-creatinine ratio, and total protein-creatinine ratio. REFERENCE TEST: Each patient had a definitive clinical diagnosis established by means of biopsy (64.4%), imaging studies (21.2%), and routine optimal microscopic examination of urine sediment (14.3%). RESULTS: Of 579 specimens, 329 were obtained from patients with glomerular disease and 250 were obtained from patients with nonglomerular disease. Mean urinary albumin-total protein, albumin-creatinine, and total protein-creatinine ratios for those with glomerular versus nonglomerular diseases were 0.73 +/- 0.11 versus 0.41 +/- 0.14 mg/mg (P < 0.001), 1,110 +/- 1,850 versus 220 +/- 560 mg/g (P < 0.001), and 1,600 +/- 3,010 versus 480 +/- 1,160 mg/g (P < 0.001), respectively. The percentage of patients with greater than 3% glomerular red cells was 83.3% versus 24.8% (P < 0.001). Receiver operating characteristic curve analysis showed that areas under the curve for albumin-total protein ratio, albumin-creatinine ratio, and total protein-creatinine ratio were 0.992, 0.781, and 0.688, respectively (P < 0.001, albumin-total protein versus albumin-creatinine; P < 0.001, albumin-total protein versus total protein-creatinine). At cutoff values of 0.59 mg/mg, 71 mg/g, and 265 mg/g, albumin-total protein ratio, albumin-creatinine ratio, and total protein-creatinine ratio had sensitivities and specificities of 97.3% and 100%, 78.9% and 61.1%, and 68.8% and 62.0% for detecting glomerular disease, respectively. Phase-contrast microscopy had sensitivity of 83.3% and specificity of 75.2% for detecting glomerular disease. LIMITATIONS: Albumin-total protein ratio cannot be used in patients with urinary total protein less than 5 mg/dL (<0.05 g/L). Use of only 1 sample from 1 patient may not be sufficient to obtain definitive results. CONCLUSIONS: Urinary albumin-total protein ratio is much more useful than phase-contrast microscopy for differentiating between glomerular and nonglomerular disease in patients with microscopic hematuria.
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