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  • Title: HIV-1 infection and hematologic picture.
    Author: Re MC, Zauli G, Furlini G, Giovannini M, La Placa M.
    Journal: Microbiologica; 1991 Apr; 14(2):165-76. PubMed ID: 1857267.
    Abstract:
    This review examines the wide spectrum of hematological abnormalities frequently observed in the peripheral blood and bone marrow of HIV-1 infected subjects. Several pathogenetic mechanisms have been implicated in the derangement of the hematopoietic system occurring during the course of HIV-1 infection: imbalance of the T-cell subpopulation (CD4/CD8 ratio), altered cytokine production by infected CD4+marrow cells, production of inhibitory factors by infected marrow stromal cells, antibody-mediated suppression of hematopoietic progenitors, direct infection of hematopoetic progenitors and/or precursors, and HIV-1 mediated suppression of CD34+ cell growth in the absence of a complete viral replication cycle. Each point is considered in the text, with particular attention to the mechanisms most likely to operate in the early stages of the syndrome.
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