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  • Title: [Polymorphism of glutathion-S-transferase genes in patients with prostatic cancer].
    Author: Davydova NA, Dmitrieva AI, Selivanov SP, Tkachenko SB, Kovalik TA, Kolomiets SA, Sevast'ianova NV, Novitskiĭ VV.
    Journal: Urologiia; 2008; (2):26-9. PubMed ID: 18572765.
    Abstract:
    The study of polymorphic variants of GSTT1, GSTM1 and GSTP1 genes from 61 patients with prostatic cancer (PC) has shown that incidence of 0/0 genotype GSTT1 and GSTM1 in PC patients was significantly higher of that in healthy men (n = 100) (34.4 and 15% in p = 0.007 and 60.7 and 43% in p = 0.04, respectively). PC risk in carriers of a GSTT1 deletion form was 2.97, CI95%--1.3-6.84, GSTM1--2.04 in CI95% 1.02-4.1. The analysis of combinations of pathological genotypes of xenobiotic biotransformation enzymes has demonstrated that 89.8% PC patients have a mutation in one of the genes GSTT1, GSTM1 or GSTP1.
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