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Title: An efficient asymmetric synthesis of manzacidin C. Author: Tran K, Lombardi PJ, Leighton JL. Journal: Org Lett; 2008 Jul 17; 10(14):3165-7. PubMed ID: 18572947. Abstract: A brief synthesis of manzacidin C based on a chiral silane-promoted diastereo- and enatioselective acylhydrazone-alkene [3 + 2] cycloaddition reaction has been achieved. This synthesis is the first synthesis of any of the manzacidins wherein the C(4) and C(6) stereocenters are established in a single highly stereoselective step.[Abstract] [Full Text] [Related] [New Search]