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  • Title: [Use of a multivariate analysis method for determining the interconnection of genetic markers with gene clusters and solution of taxonomy problems for the recombinant influenza A virus model].
    Author: Kolotvinov SV, Pocherniaeva RIa, Smirnov AI, Bolotskaia LA.
    Journal: Mol Gen Mikrobiol Virusol; 1991 Apr; (4):13-8. PubMed ID: 1857374.
    Abstract:
    The collection of influenza A viral recombinants has been studied for determining interconnection of the definite genetical marker (pneumovirulence for mice) with genes constellation by the technique of image identification. Pneumovirulence is found to be defined by correlation of polymerase complex M-, NS- and NA-genes. The data on NA influence on pneumovirulence were obtained for the first time, the phenomenon being found only with the use of image identification technique. The used methods of image identification (the method of correlation plaiads and cluster analysis) are recommended for use in studying the specificity of the gene control for different genetical features.
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