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  • Title: [Research progress of neural stem cells signal transduction pathway].
    Author: Zhang W, Wang Y, Wang X, Lv J.
    Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2008 Apr; 22(4):492-5. PubMed ID: 18575456.
    Abstract:
    OBJECTIVE: To summarize Notch, basic helix-loop-helix (bHLH) and Wnt gene signal transduction pathways in the process of differentiation and development of neural stem cells. METHODS: The literature on the gene signal transduction pathway in the process of differentiation and development of neural stem cells was searched and then summarized and analyzed. RESULTS: The formation of Nervous System resulted from common actions of multi-signal transduction pathways. There may exist a fixed threshold in the complicated selective system among Notch, bHLH and Wnt gene signal transduction pathways. CONCLUSION: At present, the specific gene signal transduction pathway of multiplication and differentiation of neural stem cells is still unclear.
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