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  • Title: [Effect of thiol-oxidizing agents on several enzymes in rat liver mitochondria].
    Author: Panchenko LF, Olfer'ev AM, Loktaeva TD, Ivkov NN, Komissarova TIu.
    Journal: Ukr Biokhim Zh; 1976; 48(4):455-9. PubMed ID: 185769.
    Abstract:
    The sulphydryl groups of nonprotein thiols and proteins of mitochondria, activity of enzymes, oxidative phosphorylation and swelling of these organellas were studied as affected by the thiol-oxidizing agents. Diamide and azoester are shown to oxidize SH-groups of mitochondria, inhibit isocytrate dehydrogenase and succinate: cytochrome oxidation and inhibits energy-dependent swelling of mitochondria. Under the effect of azoester the rate of oxygen consumption by mitochondria increases and there occurs their sharp swelling.
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