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  • Title: Quantification of regional myocardial blood flow using first-pass multidetector-row computed tomography and adenosine triphosphate in coronary artery disease.
    Author: Kido T, Kurata A, Higashino H, Inoue Y, Kanza RE, Okayama H, Higaki J, Murase K, Mochizuki T.
    Journal: Circ J; 2008 Jul; 72(7):1086-91. PubMed ID: 18577816.
    Abstract:
    BACKGROUND: The feasibility of using cardiac multidetector-row computed tomography (MDCT) technology in the quantitative assessment of myocardial blood flow (MBF) using the adenosine triphosphate (ATP) load technique was investigated in the present study. METHODS AND RESULTS: The study group comprised 14 patients (11 men, 3 women, age range 52-79 years, mean age 69.2 years) who underwent cardiac cine MDCT using the ATP-load technique. MBF was estimated from the slope of the linear regression equation with Patlak plots analysis. The overall average MBF was 1.83+/-0.62 ml . g(-1) . min(-1). Mean MBF in territories with stenosis on coronary angiography was 1.19+/-0.36 ml . g(-1) . min(-1) and 2.06+/-0.54 ml . g(-1) . min(-1) (p<0.01) in territories without stenosis. The average MBF in territories with moderate to severe ischemia on myocardial perfusion scintigraphy was 1.32+/-0.14 ml .g(-1 ). min(-1 )and 1.95+/-0.64 ml . g(-1) . min(-1) (p<0.01) in territories without ischemia. CONCLUSION: MDCT can be used to quantify MBF using first-pass dynamic data.
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