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  • Title: Synthesis and evaluation of antitubercular activity of glycosyl thio- and sulfonyl acetamide derivatives.
    Author: Ghosh S, Tiwari P, Pandey S, Misra AK, Chaturvedi V, Gaikwad A, Bhatnagar S, Sinha S.
    Journal: Bioorg Med Chem Lett; 2008 Jul 15; 18(14):4002-5. PubMed ID: 18579372.
    Abstract:
    A series of glycosyl thioacetamide and glycosyl sulfonyl acetamide derivatives have been prepared following a convenient reaction protocol and evaluated for their antitubercular activity against Mycobacterium tuberculosis H(37)Rv. Amongst 32 compounds evaluated 3 compounds were effective in inhibiting mycobacterial growth at MIC of 6.25 microg/mL, 6 compounds at MIC of 3.125 microg/mL and 1 compound at MIC of 1.56 microg/mL. All active compounds were found nontoxic in Vero cell lines and mice bone marrow macrophages.
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