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  • Title: Gamma-aminobutyric acid A receptor functional decrease in the hypothalamus during pancreatic regeneration in rats.
    Author: Kaimal SB, George KA, Paulose CS.
    Journal: Pancreas; 2008 Jul; 37(1):e20-30. PubMed ID: 18580435.
    Abstract:
    OBJECTIVE: In the present study, we investigated the alteration of gamma-aminobutyric acid A (GABAA) receptors in the hypothalamus of rats during pancreatic regeneration. METHODS: Three groups of rats were used for the study: sham operated, 72 hours partially pancreatectomized, and 7 days partially pancreatectomized. The GABA receptor assay was performed by using the [H]GABA as ligand to the Triton X-100-treated membranes, and displacement with unlabeled GABA and [H]bicuculline binding to the GABAA receptors was assayed in Triton X-100-treated synaptic membranes and displacement with unlabeled bicuculline. RESULTS: The GABA content in the brain regions and pancreas of the sham and experimental rat groups was quantified by displacement method. In the hypothalamus, the high-affinity GABAA receptor binding showed a significant decrease in maximal binding (P < 0.01) and equilibrium dissociation constant (P < 0.05) in 72 hours and 7 days partially pancreatectomized rats. The content of GABA has significantly decreased in the hypothalamus during the regeneration of pancreas. CONCLUSIONS: This effect of GABAA receptors in hypothalamus suggests a regulatory role during active regeneration of pancreas that will have significance in insulin secretion.
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