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  • Title: [Non-dietary, non-pharmacological treatment of severe hypercholesterolemia].
    Author: Hansen PS, Sølling J, Knudsen TE, Faergeman O.
    Journal: Ugeskr Laeger; 1991 Jul 15; 153(29):2046-51. PubMed ID: 1858184.
    Abstract:
    Non-dietary, non-pharmacological reduction of cholesterol in patients with severe hypercholesterolemia can be obtained by partial ileal by-pass, portacaval shunt operation or liver transplantation. A non-surgical method is apheresis, by which low density and very low density lipoproteins are removed from blood in an extracorporal circulation system. Apheresis methods include plasmapheresis, immunoadsorption, chemical affinity and Double Membrane Filtration. Treatment of a 30 year old man with severe familial hypercholesterolemia and ischaemic heart disease, by LDL-apheresis, resulted in an average decline in serum-cholesterol of 35%. LDL-apheresis is indicated in the treatment of this type of patient and in homozygous familial hypercholesterolemia.
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