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  • Title: Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen-thawed cycles: potential paternal effects on pregnancy outcomes.
    Author: Lee SH, Song H, Park YS, Koong MK, Song IO, Jun JH.
    Journal: Fertil Steril; 2009 Mar; 91(3):798-804. PubMed ID: 18582871.
    Abstract:
    OBJECTIVE: To evaluate objectively whether poor sperm quality affects sequential events from fertilization to delivery in fresh intracytoplasmic sperm injection (ICSI) and subsequent frozen-thawed embryo transfer (ET) cycles. DESIGN: Retrospective study. SETTING: University-based centers for reproductive medicine. PATIENT(S): For unbiased comparison, 206 cycles were chosen from 1,999 cycles of patients who underwent ICSI-ET and/or subsequent frozen-thawed ET. Cycles met the following criteria: day 3 ET; female age, <40 y; number of retrieved oocytes, >or=5; no split insemination; and no female factors but tubal factor. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The rates of fertilization, embryo implantation, clinical pregnancy, and delivery and sequential embryonic score (SES) were compared between normal-spermatogenesis patients (NSPs) and defective-spermatogenesis patients (DSPs). RESULT(S): Although sum SES, mean SES, and top SES of transferred embryos on day 3 were similar between NSPs and DSPs, the rates of implantation, clinical pregnancy, and delivery of NSPs were significantly higher than those of DSPs. Furthermore, subsequent ET cycles with frozen-thawed embryos in NSPs and DSPs who failed to achieve pregnancy in their fresh cycles showed that rates of implantation and clinical pregnancy also were significantly lower in DSPs. CONCLUSION(S): Quality of sperm may influence embryo implantation and subsequent pregnancy outcomes without impairment of embryo quality.
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