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  • Title: [Changes in kinetics of deaminated biogenic amines in spontaneous hypertension].
    Author: Ioffina DI, Smirnov IE, Gorkin VZ.
    Journal: Vopr Med Khim; 1991; 37(1):59-63. PubMed ID: 1858344.
    Abstract:
    Rate of serotonin and benzylamine deamination was increased in liver tissue of rats with spontaneous hypertension. The increase was due to elevation in Vmax value for monoamine oxidases of the A and B types as compared with the corresponding values of control animals. The Vmax value was increased in kidney of hypertensive animals for MAO of the B type (benzylamine as a substrate). At the same time, Km for MAO of the B type was increased in liver tissue, while Km for MAO of the A type was decreased in brain of hypertensive animals. Titration of the MAO active sites exhibited their increased concentration in the B type MAO in liver mitochondria of experimental animals. The data obtained suggest an important role of alterations in the MAO catalytic activity in pathogenesis of spontaneous hypertension.
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