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  • Title: Characterization of an immunodominant epitope of small ruminant lentivirus (SRLV) nucleoprotein.
    Author: Lacerenza D, Genovese F, Profiti M, Nucera D, Rosati S.
    Journal: Vet Immunol Immunopathol; 2008 Oct 15; 125(3-4):361-7. PubMed ID: 18584880.
    Abstract:
    To extend and complete the epitope mapping of gag-encoded structural proteins, the immunodiagnostic potential of nucleoprotein (NP) of two different small ruminant lentivirus (SRLV) genotypes were antigenically characterized. Respective recombinant counterparts were generated and used in an enzyme-linked immunosorbent assay (ELISA) format to test a panel of sera from infected flocks. Results clearly indicate that a single linear epitope located within the C-terminal is partially cross-reactive among different SRLV genotypes and may complement multiple epitope ELISA for serological diagnosis of infection. However, in contrast to matrix and capsid antigen epitopes, which drive a genotype-specific immunoresponse, a moderate degree of variation was identified in NP independently of the genotype to which it belongs.
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