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  • Title: Examination of growth inhibitory properties of synthetic chalcones for which antibacterial activity was predicted.
    Author: Batovska D, Parushev S, Stamboliyska B, Tsvetkova I, Ninova M, Najdenski H.
    Journal: Eur J Med Chem; 2009 May; 44(5):2211-8. PubMed ID: 18584918.
    Abstract:
    A large series of chalcones were synthesized and studied against Staphylococcus aureus and Escherichia coli. Chalcones were either unsubstituted in ring A or possessed 4'-chloro or 3',4',5'-trimethoxy groups. Their other ring B was variously substituted. It was found that the anti-staphylococcal activity of chalcones was related to the energy difference between the two highest occupied molecular orbitals (HOMO and HOMO-1). Presence of hydroxyl group in ring B was not a determinant factor for the anti-staphylococcal activity, but the lipophilicity of ring A of the hydroxyl chalcones was of importance.
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