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  • Title: Platelet aggregation in humans is affected by replacement of dietary linoleic acid with oleic acid.
    Author: Burri BJ, Dougherty RM, Kelley DS, Iacono JM.
    Journal: Am J Clin Nutr; 1991 Aug; 54(2):359-62. PubMed ID: 1858699.
    Abstract:
    The effect of concentrations of linoleic acid (LA) on platelet aggregation was measured in seven healthy adult males. Subjects were randomly divided into two groups; these groups were fed natural food diets of identical composition except that one was high in LA (11.5% of energy) and low in oleic acid (OA) (7.4% of energy), the other was low in LA (4.5% of energy) and high in OA (15.7% of energy). The thresholds of ADP- and collagen-induced platelet aggregation were increased significantly by the high LA diet even though the intake of total fat and saturated fatty acids did not differ in these diets.
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