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  • Title: pH and salivary sodium bicarbonate in cancer patients: correlation with seric concentration.
    Author: Rojas-Morales T, Navas R, Viera N, Alvarez CJ, Chaparro N.
    Journal: Med Oral Patol Oral Cir Bucal; 2008 Jul 01; 13(7):E456-9. PubMed ID: 18587311.
    Abstract:
    OBJECTIVE: To determine the correlation between pH and bicarbonate of soda in blood and saliva in child and adolescent patients during the administration of 3 g/m2 of methotrexate. METHOD: A controlled clinical test was performed on 23 patients diagnosed with Acute Lymphoblastic Leukemia. Ages ranged from 4 to 18. The Spearman Correlation Coefficient was used to interpret the data. RESULTS: No significant correlation was found between pH levels and seric and salivary sodium bicarbonate. However, there was a significant correlation between the levels of sodium bicarbonate in the body fluids evaluated (rs 0.2576, p=0.0354). CONCLUSIONS: Changes modifying the microenvironment of the oral cavity probably do not allow saliva to be used to determine blood pH and seric bicarbonate.
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