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  • Title: Total synthesis of (S)-(+)-tylophorine via enantioselective intramolecular alkene carboamination.
    Author: Zeng W, Chemler SR.
    Journal: J Org Chem; 2008 Aug 01; 73(15):6045-7. PubMed ID: 18588345.
    Abstract:
    The enantioselective synthesis of (S)-(+)-tylophorine, a potent cancer cell growth inhibitor, has been accomplished in eight steps from commercially available 3,4-dimethoxybenzyl alcohol. A copper (II)-catalyzed enantioselective intramolecular alkene carboamination was employed as the key step to construct the chiral indolizidine ring.
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