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  • Title: [Bioequivalence of enteric coated tablet of Zhengqing Fengtongning].
    Author: Zhang SH, Zhou YD, He HX.
    Journal: Zhongguo Zhong Yao Za Zhi; 2008 Mar; 33(6):683-5. PubMed ID: 18590201.
    Abstract:
    OBJECTIVE: To explore the pharmacokinetics and bioequivalence of two kinds of enteric coated tablet of Zhengqing Fengtongning. METHOD: A single dose of 45 mg kg(-1) test or reference preparation was administrated by randomized crossover way in 12 rabbits. The plasma concentrations of drug were determined by HPLC. The pharmacokinetics parameters and relative bioequivalence were calculated with 3p97 program. RESULT: The concentration curves based on drug-time of both test and control preparations were presented by one-compartment model, tmax were (0.81 +/- 0.34), (0.60 +/- 0.30) h respectively, Cmax were (11.16 +/- 0.58), (11.90 +/- 1.44) microg mL(1) respectively, AUC(0-->t) were (61.58 +/- 6.70), (60.56 +/- 6.67) microg h mL(-1) respectively, relative bioavailability was (102.77% +/- 15.63)%. Suggesting no significant diffirence between the main pharmacokinetic parameters of two prepations. CONCLUSION: The two preparations are bioequivalent.
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