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  • Title: Breaking down EMT.
    Author: Levayer R, Lecuit T.
    Journal: Nat Cell Biol; 2008 Jul; 10(7):757-9. PubMed ID: 18591967.
    Abstract:
    Epithelial-mesenchymal transition, in which epithelial cells lose their polarity and become motile mesenchymal cells, occurs during development and marks a key step in tumour progression towards metastasis. Most studies of this process have focused on the disassembly of adherens junctions, but regulation of basement membrane breakdown by a pathway involving RhoA and microtubules may be equally important.
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