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  • Title: General and efficient copper-catalyzed amidation of saturated C-H bonds using N-halosuccinimides as the oxidants.
    Author: Liu X, Zhang Y, Wang L, Fu H, Jiang Y, Zhao Y.
    Journal: J Org Chem; 2008 Aug 15; 73(16):6207-12. PubMed ID: 18593184.
    Abstract:
    We have developed a general and efficient method for copper-catalyzed amidation of saturated C-H bonds under mild conditions, and the used substrates include benzylic reagents, the N, N-dimethylaniline derivatives, the free carboxamides, and sulfonamides. The protocol uses inexpensive and readily available CuBr/ N-halosuccinimide (NBS or NCS) as the catalyst/oxidant, so it provides practical applications for synthesis of various amides via C-H activation.
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