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  • Title: Anti-elastin antibodies in rabbits fed an atherogenic diet.
    Author: Gmiński J, Drózdz M, Sułkowski P.
    Journal: Biomed Biochim Acta; 1991; 50(1):87-92. PubMed ID: 1859391.
    Abstract:
    Anti-elastin antibodies which seem to play an important role in atherogenesis were studied in serum of rabbits fed with a cholesterol-rich diet using the dot-immunobinding assay. These antibodies appeared only in rabbits of the experimental group after the sixth week of the experiment and a progressive rise in their titer was observed. The concentration of total serum cholesterol and the elastase-like activity in aorta which were determined additionally showed a statistically significant increase of both analyzed parameters in animals from the experimental group when compared to the controls. Anti-elastin antibodies seem to reflect an increased elastin turnover during the induction of experimental atherosclerosis.
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