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  • Title: Heterotrimeric G protein mediated regulation of proteinase production in Aspergillus nidulans.
    Author: Emri T, Szilágyi M, Justyák A, Pócsi I.
    Journal: Acta Microbiol Immunol Hung; 2008 Jun; 55(2):111-7. PubMed ID: 18595316.
    Abstract:
    Extracellular proteinase production induced by carbon starvation was studied in a series of heterotrimeric G protein signaling pathway mutants of Aspergillus nidulans. All the mutants tested--including deltafadA (Galpha), deltasfaD (Gbeta), deltagpgA (Ggamma) and deltasfgA (regulator of FadA signaling)--showed an elevated proteinase production after glucose depletion. Our results strongly support the view that during growth, FadA/SfaD/GpgA G protein signaling inhibits proteinase production via both Galpha and Gbetagamma subunits, and all conditions, which are not sufficient to support vegetative growth and, hence, inhibit this type of G protein signaling, elevate extracellular proteinase activities.
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