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  • Title: 4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.
    Author: Pace P, Spieser SA, Summa V.
    Journal: Bioorg Med Chem Lett; 2008 Jul 15; 18(14):3865-9. PubMed ID: 18595690.
    Abstract:
    The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors.
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