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  • Title: Determination of bromide in canine plasma using ion chromatography.
    Author: Cox SK, Whiton AM, Bowman HL.
    Journal: J Chromatogr B Analyt Technol Biomed Life Sci; 2008 Jul 15; 870(2):255-8. PubMed ID: 18599370.
    Abstract:
    A new ion chromatographic procedure has been developed and validated for the determination of bromide in canine plasma. Following a simple dilution, samples were separated on a Metrosep A Supp 5 column. The mobile phase was an isocratic mixture of 2.2 mM Na(2)CO(3), 1.0 mM NaHCO(3), and 1% acetonitrile, with a flow-rate of 0.7 ml/min. The procedure produced a linear curve over the concentration range of 50-2500 microg/ml. The development of the assay permitted the determination of therapeutic levels after oral administration of potassium bromide to dogs being treated for epilepsy.
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