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  • Title: Corticotropin releasing factor antagonist reduces ischemic hippocampal neuronal injury.
    Author: Lyons MK, Anderson RE, Meyer FB.
    Journal: Brain Res; 1991 Apr 05; 545(1-2):339-42. PubMed ID: 1860056.
    Abstract:
    This experiment tested the hypothesis that corticotropin-releasing factor (CRF) contributes to hippocampal ischemic injury. The antagonist to CRF (alpha-CRF) was administered intraventricularly 15 min prior to 10 min of transient forebrain ischemia in the Wistar rat. alpha-CRF demonstrated a neuroprotective effect in a dose-dependent manner most notable in CA1. There was also an increase in postischemic EEG recovery. It is postulated that CRF contributes to hippocampal ischemic injury through increased neuronal activity.
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