These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Synthesis of new carbon-11-labeled carboxamide derivatives as potential PET dopamine D3 receptor radioligands.
    Author: Gao M, Wang M, Hutchins GD, Zheng QH.
    Journal: Appl Radiat Isot; 2008 Dec; 66(12):1891-7. PubMed ID: 18602269.
    Abstract:
    Carbon-11-labeled carboxamide derivatives, (E)-4-fluoro-N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide, ([(11)C]3a), (E)-4-chloro-N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide ([(11)C]3b), (E)-4-bromo-N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide, ([(11)C]3c), (E)-4-methoxy-N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)cinnamoylamide ([(11)C]3d), N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)naphthyl-2-carboxamide ([(11)C]BP897, [(11)C]3e), and N-(4-(4-(2-[(11)C]methoxyphenyl)piperazin-1-yl)butyl)biphenyl-4-carboxamide ([(11)C]3f), have been synthesized as new potential PET radioligands for imaging of dopamine D(3) receptors. The target tracers were prepared by O-[(11)C]methylation of their corresponding precursors using [(11)C]CH(3)OTf and isolated by a simplified solid-phase extraction (SPE) purification procedure in 50-65% radiochemical yields decay corrected to end of bombardment (EOB), 20 min overall synthesis time, and 111-148GBq/micromol specific activity at end of synthesis (EOS).
    [Abstract] [Full Text] [Related] [New Search]