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  • Title: Wernicke's encephalopathy in a child with acute lymphoblastic leukemia treated with polychemotherapy.
    Author: Brück W, Christen HJ, Lakomek H, Hanefeld F, Friede RL.
    Journal: Clin Neuropathol; 1991; 10(3):134-6. PubMed ID: 1860271.
    Abstract:
    We report on a 3 3/4-year-old girl with acute lymphoblastic leukemia. Polychemotherapy caused a complete remission of the tumor. Six months after treatment was started, the patient developed vomiting and diarrhea necessitating parenteral nutrition. Disturbance of eye movements appeared 4 weeks later. The patient died suddenly 3 days after their manifestation. Autopsy revealed Wernicke's encephalopathy. This case demonstrates the need for thiamine substitution in infants with malignant diseases.
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