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  • Title: A targetable fluorescent probe for imaging hydrogen peroxide in the mitochondria of living cells.
    Author: Dickinson BC, Chang CJ.
    Journal: J Am Chem Soc; 2008 Jul 30; 130(30):9638-9. PubMed ID: 18605728.
    Abstract:
    We present the design, synthesis, and biological applications of mitochondria peroxy yellow 1 (MitoPY1), a new type of bifunctional fluorescent probe for imaging hydrogen peroxide levels within the mitochondria of living cells. MitoPY1 combines a chemoselective boronate-based switch and a mitochondrial-targeting phosphonium moiety for detection of hydrogen peroxide localized to cellular mitochondria. Confocal microscopy and flow cytometry experiments in a variety of mammalian cell types show that MitoPY1 can visualize localized changes in mitochondrial hydrogen peroxide concentrations generated by situations of oxidative stress.
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