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  • Title: Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers.
    Author: Barbaras D, Kaiser M, Brun R, Gademann K.
    Journal: Bioorg Med Chem Lett; 2008 Aug 01; 18(15):4413-5. PubMed ID: 18606541.
    Abstract:
    The quaternary beta-carbolinium alkaloid nostocarboline from the cyanobacterium Nostoc 78-12A and 10 bis-cationic dimeric derivatives were evaluated against four protozoan parasites and low micromolar values against Trypanosoma brucei, submicromolar values against Leishmania donovani and low nanomolar values against Plasmodium falciparum K1 were determined. Selectivity against rat myoblasts (L6 cells) was found to be up to >2500-fold.
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