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  • Title: Activation of vocal fold healing with topical vitamin A in rabbits.
    Author: Akdogan O, Selcuk A, Ozcan I, Ozcan KM, Giray SG, Dere H, Ozogul C.
    Journal: Acta Otolaryngol; 2009 Feb; 129(2):220-4. PubMed ID: 18607938.
    Abstract:
    CONCLUSION: The results suggest that vitamin A can prevent scar formation in the vocal fold after surgery. OBJECTIVES: This study aimed to evaluate the effects of topically applied vitamin A on healing after vocal fold trauma. MATERIALS AND METHODS: Vocal folds of 20 adult rabbits were traumatized unilaterally. Ten of them were treated with topical application of vitamin A and the others served as controls. All animals were sacrificed after 10 days. Vocal folds were resected for analysis by light microscopy. RESULTS: The untreated vocal folds showed extensive deposition of collagen and fibroblast on light microscopy and vocal folds treated with vitamin A showed less deposition. There was a significant difference between the two groups according to the percentage of collagen and fibroblasts in the lamina propria (p<0.01).
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