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  • Title: p53, epidermal growth factor receptor and proliferating cell nuclear antigen in laryngeal squamous cell carcinoma are not predictive markers for the effect of adjuvant radiotherapy.
    Author: Jiang H, Yang BB.
    Journal: Acta Otolaryngol; 2009 Jan; 129(1):101-7. PubMed ID: 18607952.
    Abstract:
    CONCLUSION: These data indicate that the expression of p53, epidermal growth factor receptor (EGFR) or proliferating cell nuclear antigen (PCNA) is not a reliable predictor of the prognosis or the effect of adjuvant radiotherapy in patients with laryngeal squamous cell carcinoma (LSCC). OBJECTIVE: The aim of this study was to investigate the prognostic significance of p53, EGFR, and PCNA in LSCC and to assess the relationships between the expression of these molecular markers and the effect of adjuvant radiotherapy. PATIENTS AND METHODS: We retrospectively reviewed the expression of these molecular markers in 75 patients with LSCC. RESULTS: None of the expressions of these molecular markers was associated with disease-free survival or overall survival and no significant correlations were found between them and the effect of adjuvant radiotherapy. Also, they were not associated with each other.
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