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  • Title: Synthesis of azatricyclodiones & octahydro-benzo[f]isoindoles and their antimicrobial evaluation.
    Author: Saxena N, Singh NT, Mishra M, Keshava GB, Shukla PK, Tripathi RP.
    Journal: J Enzyme Inhib Med Chem; 2008 Aug; 23(4):476-82. PubMed ID: 18608770.
    Abstract:
    A series of azatricyclodiones and octahydro-benzo[f]isoindoles have been synthesized by (4+2) Diels-Alder cycloaddition of maleimides with furfuryl amine. Reaction of azatricyclodiones with isocyanates led to the respective ureides. All of the compounds were screened against a number of bacteria and fungi. One of the compounds (2) displayed moderate antitubercular activity while two compounds (2) and (4) inhibited the fungal growth at 25 μg/mL.
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