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  • Title: Autoimmune enteropathy in Swedish children, 1985-2002: a call for strict diagnostic criteria.
    Author: Marthinsen LM, Scott H, Ejderhamn J.
    Journal: Scand J Gastroenterol; 2008; 43(9):1102-7. PubMed ID: 18609171.
    Abstract:
    OBJECTIVE: To investigate the incidence, prevalence and the long-term outcome of autoimmune enteropathy in Sweden. MATERIAL AND METHODS: In 2002 a questionnaire was sent to all paediatric departments in Sweden asking them to report all known cases of this condition from the period 1985-2002. RESULTS: The response rate was 92%. Five patients were reported and 3 were included in the study. Only one patient fulfilled all the diagnostic criteria and two were considered as possible cases of autoimmune enteropathy. The incidence was 0.06 to 0.12 x 10(-5) and the prevalence was 0.05 to 0.10 x 10(-5) for children aged 0-16 years. At the end of the study period all 3 patients were still alive. Two boys were receiving immunosuppressive treatment and one girl was in remission and functioning well on a gluten-free diet only. One of the patients had adrenalitis. This combination has not been reported previously in autoimmune enteropathy. CONCLUSIONS: Autoimmune enteropathy in its severe forms is a rare disease in Sweden. None of the patients reported died during the study period. Comparative studies are difficult as different diagnostic criteria are used to diagnose this disease.
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