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  • Title: [Genetics factors determining predisposition to chronic course of virus hepatitis and fibrosis in liver].
    Author: Goncharova IA, Beloborodova EV, Freĭdin MB, Beloborodova EI, Chernogoriuk GE, Puzyrev VP.
    Journal: Mol Biol (Mosk); 2008; 42(2):238-41. PubMed ID: 18610831.
    Abstract:
    Polymorphic variants of several genes IL4 C(-590)T, IL4RA Ile50Val, TNF G(-308)A were studied for their association with extent of the disease chronization which is marked by hepatic fibrosis stage. Gradual decrease in A allele frequency of polymorphic marker G(-308)A in TNF gene, from patients with weak fibrosis to patients with cirrhosis. Group of patients with weak fibrosis was characterized by higher frequency of A allele (24.5%) comparing with patients with moderate and pronounced fibrosis (13.4%) and cirrhosis (8.7%). Differences in heterozygous genotype frequencies of IL4 C(-590)T were found between patients with cirrhosis (68.2%) and groups of patients with moderate and marked fibrosis (39.1%).
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