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  • Title: Direct catalytic asymmetric Mannich-type reaction of beta-keto phosphonate using a dinuclear Ni2-Schiff base complex.
    Author: Chen Z, Yakura K, Matsunaga S, Shibasaki M.
    Journal: Org Lett; 2008 Aug 07; 10(15):3239-42. PubMed ID: 18610973.
    Abstract:
    Direct catalytic asymmetric Mannich-type reactions of beta-keto phosphonates are described. A homodinuclear Ni 2-Schiff base complex promoted the reaction at 0 degrees C, giving beta-amino phosphonates in up to 90% yield, 20:1 dr, and 99% ee. Control experiments suggested that two Ni metals are important for achieving high yield and stereoselectivity.
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