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  • Title: The effect of a combination of ampicillin and sulbactam against clinical isolates of anaerobic bacteria.
    Author: Werner H, Heizmann W, Heilmann F.
    Journal: Int J Antimicrob Agents; 1996 Apr; 6 Suppl():S27-30. PubMed ID: 18611716.
    Abstract:
    The antimicrobial susceptibility of 196 recent clinical isolates of anaerobic bacteria to ampicillin alone, ampicillin plus 1 mug/ml sulbactam, ampicillin plus 5 mug/ml sulbactam, and cefoxitin was studied by means of agar dilution tests. The ampicillin/sulbactam combination was most effective against species of the Bacteroides fragilis group, the minimum inhibitory concentration (MIC)(90) of ampicillin plus 5 mug/ml sulbactam for B. fragilis being 1 mug/ml, compared with 256 mug/ml of amoicillin, 4 mug/ml of ampicillin plus 1 mug/ml sulbactam, and 8 mug/ml of cefoxitin. No significant difference between ampicillin alone and in combination with sulbactam was observed against Gram-positive anaerobic rods or cocci.
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